Ventricle segmentation is a challenging technique for the development of detection system of ischemic stroke in computed\ntomography (CT), as ischemic stroke regions are adjacent to the brain ventricle with similar intensity. To address this problem, we\ndeveloped an objective segmentation system of brain ventricle in CT.The intensity distribution of the ventricle was estimated based\non clustering technique, connectivity, and domain knowledge, and the initial ventricle segmentation results were then obtained. To\nexclude the stroke regions from initial segmentation, a combined segmentation strategy was proposed, which is composed of three\ndifferent schemes: (1) the largest three-dimensional (3D) connected component was considered as the ventricular region; (2) the\nbig stroke areas were removed by the image difference methods based on searching optimal threshold values; (3) the small stroke\nregions were excluded by the adaptive template algorithm.The proposed method was evaluated on 50 cases of patients with ischemic\nstroke.The mean Dice, sensitivity, specificity, and root mean squared error were 0.9447, 0.969, 0.998, and 0.219 mm, respectively.\nThis system can offer a desirable performance. Therefore, the proposed system is expected to bring insights into clinic research and\nthe development of detection system of ischemic stroke in CT.
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